#Install tinkertool 6 update#
Tinker 8 is a major update of the Ponder Lab tool set for molecular mechanics and dynamics calculations.
#Install tinkertool 6 software#
The Tinker software contains a variety of interesting algorithms such as: flexible implementation of atomic multipole-based electrostatics with explicit dipole polarizability, various continuum solvation treatments including several generalized Born (GB/SA) models, generalized Kirkwood implicit solvation for AMOEBA, an interface to APBS for Poisson-Boltzmann calculations, efficient truncated Newton (TNCG) local optimization, surface areas and volumes with derivatives, free energy calculations via the Bennett Acceptance Ratio (BAR) method, normal mode vibrational analysis, minimization in Cartesian, torsional or rigid body space, symplectic RESPA multiple time step integration for molecular dynamics, velocity Verlet stochastic dynamics, pairwise neighbor lists and splined spherical energy cutoff methods, particle mesh Ewald (PME) summation for partial charges and polarizable multipoles, a novel reaction field treatment of long range electrostatics, fast distance geometry metrization with better sampling than standard methods, Elber's reaction path algorithm, potential smoothing and search (PSS) methods for global optimization, Monte Carlo Minimization (MCM) for efficient potential surface scanning, tools for fitting charge, multipole and polarization models to QM-based electrostatic potentials and more. Parameter sets for other widely-used force fields are under consideration for future releases. Tinker has the ability to use any of several common parameter sets, such as Amber (ff94, ff96, ff98, ff99, ff99SB), CHARMM (19, 22, 22/CMAP), Allinger MM (MM2-1991 and MM3-2000), OPLS (OPLS-UA, OPLS-AA), Merck Molecular Force Field (MMFF), Liam Dang's polarizable model, and the AMOEBA, AMOEBA+ and HIPPO polarizable atomic multipole force fields. The Tinker molecular modeling software is a complete and general package for molecular mechanics and dynamics, with some special features for biopolymers.
#Install tinkertool 6 download#
Tinker Tool is free, so my best recommendation is to just download it and try it for yourself.Tinker: Software Tools for Molecular Design Introduction
I also like the fact that Tinker Tool is its own application that I can get straight from the developer, without submitting to The Tyranny Of The App Store™, which takes version control and configurability away from the user.an intrusive abomination that stomps the Mac's traditional freedom of user choice into the dirt.
I suspect most users don't need that feature, but when you do need it, it's mighty handy. It's handy to be able to toggle visibility on hidden files. One of the features I use most is "Show hidden and system files" under Finder options in the Finder tab. I'm not afraid of using CLI, but I'd much rather use the graphical user interface (GUI), which is really what the Mac was supposed to be all about. Tinker Tool does just what it says it enables the user to access and tweak various under-the-hood features of OS X, many of which you'd have to otherwise control using the command line interface (CLI) in Terminal.app.
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